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54 Furthermore, it has been demonstrated that dysregulated glutathionylation processes contribute to the etiology of numerous human illnesses, such as lung, 55 neurological, 56 , 57 cardiovascular, 58 cataract, 59 and liver disease

GSH is a tripeptide composed of the amino acids glutamate, cysteine and glycine (Figure 3a)

Although several laboratory and animal studies suggest potential regenerative effects, there are scant high-quality randomized controlled human trials demonstrating its safety or efficacy

Strengths, Limitations, and Future Directions The strength of the current study is the utilization of multiple controls to assess skeletal muscle redox signaling: Internal contralateral unstimulated control limbs compared to stimulated limbs, as well as Nave Control animals with control limbs and mock stimulated control limbs